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After two decades of research, scientists at the Rambam healthcare campus in Haifa and the Technion-Israel Institute of Technology have found a way to rejuvenate the skin and human organs. The successful study was performed on mice under laboratory conditions and has just been published in the journal Science Advances, published by the American Association for the Advancement of Science.
Sipas The Jerusalem Post , autorët e studimit përdorën një shartim të lëkurës së plakur të njeriut tek minjtë e rinj dhe vërtetuan se është e mundur që lëkura dhe organet e tjera të bëhen sërish të reja duke ndryshuar strukturën molekulare nëpër të gjitha shtresat e lëkurës. Shkencëtarët nga Laboratori i Manastirit në Gjermani dhe nga Universiteti i Mançesterit e titulluan studimin e tyre, "Përtëritja e organeve të njeriut nga VEGF-A: Mësime nga lëkura".
Shkencëtarët transplantuan lëkurën e plakur të njeriut tek minjtë e rinj me sëmundje të rëndë të mungesës së imunitetit të kombinuar (SCID) që prek të dy limfocitet B dhe T. Kjo mund të rinovojë transplantimin e qelizave, indeve ose organeve të gjalla nga një specie në tjetrën, thanë shkencëtarët. Ky proces shoqërohet me rritjen e enëve të reja të gjakut, ripigmentimin e shtresës së jashtme të lëkurës të quajtur epidermë dhe përmirësim të ndjeshëm në biomarkerët e plakjes, thotë Post.
Shkencëtarët vunë në dukje se në vend që ta shikojnë plakjen si një sëmundje fatale, ndryshimi i pikëpamjes së plakjes si një “objektiv i barnueshëm dhe i riprogramueshëm, zbërthimi i shtytësve kryesorë të plakjes së organeve njerëzore dhe zhvillimi i strategjive molekulare efektive për ta parandaluar apo edhe për ta kthyer atë, sigurisht që përbën një nga misionet më themelore të kërkimit biomjekësor.”
Lëkura e njeriut është një model ideal i kërkimit paraklinik për të hetuar metodat kundër plakjes pasi është organi i parë i trupit të njeriut që pasqyron dukshëm ndryshimet në plakje, si ndryshimet në tonin e lëkurës dhe thinjat e flokëve.
The promising study found that not only was the outer layer of human skin renewed when grafted on SCID mice, but also all skin layers could become new again. To determine this, they used vascular endothelial growth factor A (VEGF-A) to assess the process and in addition found that the number of new blood vessels in the transplanted skin also increased./ AE-CNA.al
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