web counter
LEXO PA REKLAMA!

SHKARKO APP

App Store
Google Play

STUDY/ Alzheimer's may be an inherited form of the disorder

2024-05-08 10:04:00, Shëndeti CNA
STUDY/ Alzheimer's may be an inherited form of the disorder
Illustrative photo

Alzheimer's disease may be inherited more often than previously known, according to a new study that provides a clearer picture of a gene long known to be linked to the common form of dementia, CNN reports. 

The authors of the study, published Monday in the journal Nature Medicine, say this may also be considered a distinct, inherited form of the disease and that different approaches to testing and treatment may be needed.

Among people diagnosed with Alzheimer's, researchers recognize familial forms of the disease and sporadic cases. Most cases are thought to be sporadic, developing later in life. Familial forms, caused by mutations in any of the three genes, tend to strike earlier and are known to be rare, accounting for about 2% of all Alzheimer's diagnoses, or about 1 in 50 cases.

Under the new paradigm, 1 in 6 cases of Alzheimer's would be considered inherited, or familial.

There are three types of APOE gene that a person can carry. One called APOE2 is thought to be protective against the development of Alzheimer's disease. APOE3 is thought to confer a neutral disease risk.

APOE4, on the other hand, is bad news. It has long been recognized that people with at least one copy of the APOE4 gene have a high risk of developing Alzheimer's disease, while people with two copies had an even higher risk.

Now, researchers say APOE4 should not just be recognized as a risk factor, but should be seen as an inherited form of the disease, virtually ensuring that a person who has two copies will get the biological changes associated with Alzheimer's disease in the brain. theirs./ CNA 

 





Lajmet e fundit nga